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This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
Gene Name: | interferon gamma receptor 2 (interferon gamma transducer 1) |
Family/Subfamily: | Interferon Receptor , not assigned-Interferon Receptor |
Synonyms: | IFNGR2, AF-1, IFN-gamma receptor 2, IFGR2, IFNGT1, Interferon gamma receptor 2, Interferon gamma transducer 1, IFN-gamma-R2 |
Target Sequences: | NM_005534 NP_005525.2 P38484 |
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