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IFIX / PYHIN1 belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene Name: | pyrin and HIN domain family, member 1 |
Synonyms: | PYHIN1, IFIX, RP11-520H16.1 |
Target Sequences: | Q6K0P9 Q6K0P9 |
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