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Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.
Gene Name: | interferon-induced protein with tetratricopeptide repeats 5 |
Synonyms: | IFIT5, IFIT-5, p58, RI58 |
Target Sequences: | NM_012420 NP_036552.1 Q13325 |
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