IFIT3

interferon-induced protein with tetratricopeptide repeats 3

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.

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Products

Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

IFIT3 (10)

Publications

No (10)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-SUMO (1)

Myc-DDK (Flag) (6)

Species

Human (8)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human IFIT3 Protein (Recombinant His) - LS-G3325

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human IFIT3 Protein (Recombinant GST, N-terminus) (aa392-490) - LS-G58942

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human IFIT3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67645

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.8 kDa

Price:

20 µg/$1,107

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Human IFIT3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67647

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.8 kDa

Price:

20 µg/$1,107

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Human IFIT3 Protein (Recombinant His-SUMO) (Full Length) - LS-G20846

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

71.9 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human IFIT3 Protein (Recombinant GST) (Full Length) - LS-G28978

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

82.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Human IFIT3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80371

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.8 kDa

Price:

20 µg/$215

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Human IFIT3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80372

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.8 kDa

Price:

20 µg/$150

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IFIT3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120457

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.8 kDa

Price:

100 µg/$710

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IFIT3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99477

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.8 kDa

Price:

100 µg/$494

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