IFIT1 / ISG56

interferon-induced protein with tetratricopeptide repeats 1

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.

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Products

Proteins (4)

Type

Over-Expression Lysate (1)

Recombinant (3)

Target

IFIT1 / ISG56 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human IFIT1 / ISG56 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66083

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.2 kDa

Price:

20 µg/$1,107

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IFIT1 / ISG56 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99475

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.2 kDa

Price:

100 µg/$494

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Human IFIT1 / ISG56 Protein (Recombinant GST) (Full Length) - LS-G28977

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

81.8 kDa

Price:

2 µg/$439

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Human IFIT1 / ISG56 Protein (Recombinant GST, N-terminus) (aa318-420) - LS-G58943

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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