IFIH1 / MDA5

interferon induced with helicase C domain 1

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

IFIH1 / MDA5 (8)

Publications

No (8)

Tag

6His, N-terminus (1)

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

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Human IFIH1 / MDA5 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69112

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

116.5 kDa

Price:

20 µg/$1,107

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Human IFIH1 / MDA5 Protein (Recombinant His) (aa605-815) - LS-G26121

Source:

E. coli

Tag:

His

Molecular Weight:

28.2 kDa

Price:

10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136

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Human IFIH1 / MDA5 Protein (Recombinant 6His, N-terminus) (aa700-1025) - LS-G56956

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human IFIH1 / MDA5 Protein (Recombinant GST) (Full Length) - LS-G34942

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

51.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human IFIH1 / MDA5 Protein (Recombinant GST, N-terminus) (aa928-1023) - LS-G63073

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human IFIH1 / MDA5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83864

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

116.5 kDa

Price:

20 µg/$215

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IFIH1 / MDA5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110408

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

116.5 kDa

Price:

100 µg/$710

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Human IFIH1 / MDA5 Protein (Recombinant 6His-SUMO, N-terminus) (aa700-1025) - LS-G56955

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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