IFIH1 / MDA5

interferon induced with helicase C domain 1

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.

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Products

Antibodies (55)

Proteins (8)

ELISA Kits (4)

Type

Over-Expression Lysate (2)

Primary (55)

Recombinant (6)

Sandwich (4)

Target

IFIH1 / MDA5 (67)

Reactivity

Human (56)

Mouse (15)

Rat (4)

Bovine (3)

Chimpanzee (3)

Horse (3)

Monkey (1)

Pig (3)

Application

IHC (13)

IHC-P (12)

WB (46)

ELISA (14)

ICC (1)

IF (6)

IP (5)

Peptide-ELISA (4)

Host

rabbit (38)

mouse (14)

goat (3)

Product Group

IHCPlus (3)

PathPlus Cancer (1)

Isotype

IgG (24)

IgG1 (8)

IgG2a (4)

IgG2a,k (1)

Clonality

monoclonal mc (14)

polyclonal pc (41)

Clone

1B6 (1)

3F6 (1)

Hely-1 (1)

OTI11C11 (2)

OTI12A6 (2)

OTI1C7 (2)

OTI3E10 (2)

OTI8C10 (2)

Format

96-Well Strip Plate (4)

APC (1)

APC Conjugated (2)

Biotin Conjugated (4)

Carrier-free (5)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (2)

Unconjugated (37)

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Epitope

aa605-815 (8)

aa612-661 (4)

940-1020 aa, C-terminal (1)

Arg470 (1)

C-Terminus (1)

Internal Region (1)

N-Terminal (1)

N-Terminus (1)

aa1-205 (1)

aa78-555 (1)

aa976-1025 (1)

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Publications

No (66)

Yes (1)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (3)

Tag

6His, N-terminus (1)

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

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IHC-plus™ IFIH1 / MDA5 Antibody LS-B2107

(4.0) Rating

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$545

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IFIH1 / MDA5 Antibody (Arg470) LS-C191022

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Monoclonal (Arg470) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$688

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IFIH1 / MDA5 Antibody (C-Terminus) LS-C353529

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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IFIH1 / MDA5 Antibody (clone 3F6) LS-C134094

Antibody:

IFIH1 / MDA5 Mouse anti-Human Monoclonal (3F6) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

100 µg/$423

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IFIH1 / MDA5 Antibody (N-Terminus) LS-C55097

(4.0) Rating

(1) Publication(s)

Antibody:

IFIH1 / MDA5 Goat anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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Human IFIH1 / MDA5 (Sandwich ELISA) ELISA Kit - LS-F33771

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$587

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Human IFIH1 / MDA5 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69112

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

116.5 kDa

Price:

20 µg/$1,107

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Mouse IFIH1 / MDA5 (Sandwich ELISA) ELISA Kit - LS-F19794

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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IFIH1 / MDA5 Antibody LS-C331984

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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IFIH1 / MDA5 Antibody LS-C193107

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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IHC-plus™ IFIH1 / MDA5 Antibody LS-B2349

(4.0) Rating

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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PathPlus™ IFIH1 / MDA5 Antibody LS-A10978

Cancer

Fast Shipping

(5.0) Rating

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal Antibody

Applications:

IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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Human IFIH1 / MDA5 (Sandwich ELISA) ELISA Kit - LS-F13243

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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IFIH1 / MDA5 Antibody (aa612-661) LS-B5622

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal (aa612-661) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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IFIH1 / MDA5 Antibody LS-C343697

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µg/$563

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IFIH1 / MDA5 Antibody LS-C398404

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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IFIH1 / MDA5 Antibody (Biotin) LS-C398607

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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IFIH1 / MDA5 Antibody (aa605-815, Biotin) LS-C425042

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal (aa605-815) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$329; 200 µl/$381; 500 µl/$550; 1 ml/$654; 2 ml/$890; 5 ml/$1,487

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Human IFIH1 / MDA5 Protein (Recombinant His) (aa605-815) - LS-G26121

Source:

E. coli

Tag:

His

Molecular Weight:

28.2 kDa

Price:

10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136

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Human IFIH1 / MDA5 Protein (Recombinant 6His, N-terminus) (aa700-1025) - LS-G56956

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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IFIH1 / MDA5 Antibody LS-C804589

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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IFIH1 / MDA5 Antibody (940-1020 aa, C-terminal) LS-C384473

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal (940-1020 aa, C-terminal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

IFIH1 / MDA5 Antibody (aa1-205) LS-C379837

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal (aa1-205) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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IFIH1 / MDA5 Antibody (aa78-555, clone Hely-1) LS-C344935

Antibody:

IFIH1 / MDA5 Mouse anti-Human Monoclonal (aa78-555) (Hely-1) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$477

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IFIH1 / MDA5 Antibody LS-C666312

Antibody:

IFIH1 / MDA5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$351

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