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IFI30 / IP30

Interferon, Gamma-inducible Protein 30

Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation.

Gene Name: Interferon, Gamma-inducible Protein 30
Synonyms: IFI30, GILT, Legumaturain, IFI-30, IP30
Target Sequences: NM_006332 NP_006323.2 P13284

Publications (1)

1
A non-immunological role for ?-interferon-inducible lysosomal thiol reductase (GILT) in osteoclastic bone resorption. Benjamin W Ewanchuk , Corey R Arnold , Dale R Balce, Priyatha Premnath, Tanis L Orsetti, Amy L Warren, Alexandra Olsen, Roman J Krawetz, Robin M Yates. Science advances. 2021 Apr;7:eabd3684. [Full Text Article] [PubMed:33893096] [PMC:PMC8064644]

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Products
Proteins (10)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (6)
IFI30 / IP30 (10)
SDS-PAGE (1)
No (9)
Yes (1)
GST (1)
His (1)
His, N-Terminal (3)
His,C-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (9)
293T Cells (1)
E. coli (3)
HEK 293 Cells (5)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (1)
IFI30 / IP30 Protein
Select
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human IFI30 is a disulfide-linked homodimer. The reduced monomer comprises 217 amino acids and has a predicted molecular mass of 24.7 kDa. The apparent molecular mass of the protein is approximately 31-34 kDa in SDS-PAGE under reducing conditions.
100 µg/$480
IFI30 / IP30 Protein
Select
E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
Select
HEK 293 Cells
His, N-Terminal
~20 kDa
100 µg/$298
Select
HEK 293 Cells
His, N-Terminal
~20 kDa
200 µl/$283
IFI30 / IP30 Protein - Recombinant Interferon Gamma Inducible Protein 30 By SDS-PAGE
Select
E. coli
His-T7
33.7 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
IFI30 / IP30 Protein
Select
E. coli
His, N-Terminal
24 kDa
10 µg/$265; 100 µg/$365; 50 µg/$315
IFI30 / IP30 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.96 kDa
20 µg/$150
IFI30 / IP30 Protein - 12.5% SDS-PAGE of human IFI30 stained with Coomassie Blue
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Wheat Germ Extract
GST
54.4 kDa
10 µg/$479; 25 µg/$670
IFI30 / IP30 Protein - Purified recombinant protein IFI30 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
25.2 kDa
20 µg/$1,107
IFI30 / IP30 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
27.96 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).