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IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity.
Gene Name: | isopentenyl-diphosphate delta isomerase 1 |
Synonyms: | IDI1, IPP1, IPPI1, Homolog of yeast ipp isomerase, IPP isomerase 1 |
Target Sequences: | NM_004508 NP_004499.2 Q13907 |
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