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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.
Gene Name: | isocitrate dehydrogenase 2 (NADP+), mitochondrial |
Synonyms: | IDH2, D2HGA2, ICD-M, IDP, IDPM, MNADP-IDH, NADP(+)-specific ICDH, IDH, IDHM, Isocitrate dehydrogenase, Oxalosuccinate decarboxylase |
Target Sequences: | NM_002168 NP_002159.2 P48735 |
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