IDH1 / IDH

isocitrate dehydrogenase 1 (NADP+), soluble

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

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Products

Proteins (33)

Type

Over-Expression Lysate (2)

Recombinant (31)

Target

IDH1 / IDH (33)

Publications

No (33)

Tag

6His, C-terminus (2)

8His, C-terminus (4)

DDK,C-terminus (10)

GST (2)

His (5)

His,C-terminus (1)

His-GST (1)

Myc-DDK (Flag) (3)

Myc-DDK (Flag), C-terminus (5)

Species

Human (29)

Mouse (2)

Rat (1)

Source

293T Cells (1)

E. coli (10)

HEK 293 Cells (7)

Human Cells (1)

Mammalian Cells (1)

Sf9 Cells (11)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (6)

Biologically Active

Biologically active (1)

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Human IDH1 / IDH Protein (Recombinant 8His, C-terminus) (Met1-Leu414) - LS-G40179

Source:

E. coli

Tag:

8His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

48.1kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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Human IDH1 / IDH Protein (Recombinant His) (aa74-333) - LS-G15955

Source:

E. coli

Tag:

His

Molecular Weight:

30.8 kDa

Price:

10 µg/$279; 50 µg/$425; 100 µg/$680; 200 µg/$850; 1 mg/$1,944; 500 µg/$1,490; 5 mg/$2,969; 2 mg/$2,131

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Mouse IDH1 / IDH Protein (Recombinant His-GST) (aa99-325) - LS-G15956

Source:

E. coli

Tag:

His-GST

Molecular Weight:

57.6 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Rat IDH1 / IDH Protein (Recombinant His) (aa78-330) - LS-G15959

Source:

E. coli

Tag:

His

Molecular Weight:

30.2 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Mouse IDH1 / IDH Protein (Recombinant His) (aa7-407) - LS-G20840

Source:

E. coli

Tag:

His

Molecular Weight:

49.2 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human IDH1 / IDH Protein (Recombinant His) - LS-G1509

Source:

E. coli

Tag:

His

Biological Activity:

Biologically active

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human IDH1 / IDH Protein (Recombinant His) (Met1-Leu414) - LS-G97561

Source:

E. coli

Tag:

His

Molecular Weight:

48 kDa

Price:

50 µg/$997; 1 mg/$5,281

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Human IDH1 / IDH Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68223

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.5 kDa

Price:

20 µg/$1,107

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Human IDH1 / IDH Protein (Recombinant 6His, C-terminus) (Met1-Leu414) - LS-G140494

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

47.7 kDa

Price:

10 µg/$344; 50 µg/$584

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Human IDH1 / IDH Protein (Recombinant DDK,C-terminus) - LS-G142351

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

47 kDa

Price:

20 µg/$677

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Human IDH1 / IDH Protein (Recombinant DDK,C-terminus) - LS-G142353

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

47 kDa

Price:

20 µg/$677

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Human IDH1 / IDH Protein (Recombinant DDK,C-terminus) - LS-G142352

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

47 kDa

Price:

20 µg/$677

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Human IDH1 / IDH Protein (Recombinant Myc-DDK (Flag), C-terminus) - LS-G142169

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag), C-terminus

Molecular Weight:

46 kDa

Price:

20 µg/$1,107

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Human IDH1 / IDH Protein (Recombinant Myc-DDK (Flag), C-terminus) - LS-G142172

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag), C-terminus

Molecular Weight:

46 kDa

Price:

20 µg/$1,107

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Human IDH1 / IDH Protein (Recombinant Myc-DDK (Flag), C-terminus) - LS-G142173

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag), C-terminus

Molecular Weight:

46 kDa

Price:

20 µg/$1,107

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Human IDH1 / IDH Protein (Recombinant Myc-DDK (Flag), C-terminus) - LS-G142171

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag), C-terminus

Molecular Weight:

46 kDa

Price:

20 µg/$1,107

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Human IDH1 / IDH Protein (Recombinant His,C-terminus) - LS-G142343

Source:

Sf9 Cells

Tag:

His,C-terminus

Molecular Weight:

47 kDa

Price:

20 µg/$677

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Human IDH1 / IDH Protein (Recombinant DDK,C-terminus) - LS-G142344

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

47 kDa

Price:

20 µg/$677

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Human IDH1 / IDH Protein (Recombinant DDK,C-terminus) - LS-G142345

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

47 kDa

Price:

20 µg/$677

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Human IDH1 / IDH Protein (Recombinant DDK,C-terminus) - LS-G142346

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

47 kDa

Price:

20 µg/$677

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Human IDH1 / IDH Protein (Recombinant DDK,C-terminus) - LS-G142347

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

47 kDa

Price:

20 µg/$677

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Human IDH1 / IDH Protein (Recombinant DDK,C-terminus) - LS-G142348

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

47 kDa

Price:

20 µg/$677

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Human IDH1 / IDH Protein (Recombinant DDK,C-terminus) - LS-G142349

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

47 kDa

Price:

20 µg/$677

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Human IDH1 / IDH Protein (Recombinant Myc-DDK (Flag), C-terminus) - LS-G142170

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag), C-terminus

Molecular Weight:

46 kDa

Price:

20 µg/$1,107

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Human IDH1 / IDH Protein (Recombinant DDK,C-terminus) - LS-G142350

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

47 kDa

Price:

20 µg/$677

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