IDE

insulin-degrading enzyme

IDE is a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

IDE (9)

Publications

No (9)

Tag

6His, C-terminus (2)

GST (1)

GST, N-terminus (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Source

293T Cells (1)

Baculovirus (1)

E. coli (1)

HEK 293 Cells (2)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (3)

Biologically Active

Biologically active (1)

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Human IDE Protein (Recombinant GST) (Full Length) - LS-G28965

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

144.4 kDa

Price:

2 µg/$439

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Human IDE Protein (Recombinant His-T7) (aa753-973) - LS-G14436

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.7 kDa

Price:

10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298

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Human IDE Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66030

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

117.8 kDa

Price:

20 µg/$1,107

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Human IDE Protein (Recombinant GST, N-terminus) (aa920-1019) - LS-G58932

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human IDE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76781

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

117.8 kDa

Price:

20 µg/$215

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Human IDE Protein (Recombinant His) - LS-G146745

Source:

Baculovirus

Tag:

His

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

114 kDa

Price:

50 µg/$395; 100 µg/$575; 500 µg/$1,710; 10 µg/$255; 20 µg/$325; 250 µg/$995

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IDE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100429

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

117.8 kDa

Price:

100 µg/$710

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Human IDE Protein (Recombinant 6His, C-terminus) (Met42-Leu101) - LS-G39275

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

114.25kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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Human IDE Protein (Recombinant 6His, C-terminus) (Met42-Leu1019) - LS-G140222

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

114.3 kDa

Price:

10 µg/$344; 50 µg/$584

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