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Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
Gene Name: | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
Synonyms: | ID1, BHLHb24, ID, Inhibitor of differentiation 1, Inhibitor of DNA binding 1, DJ857M17.1.2 |
Target Sequences: | NM_002165 NP_002156.2 P41134 |
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