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ICAM2 / CD102 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene.
Gene Name: | intercellular adhesion molecule 2 |
Family/Subfamily: | ICAM , not assigned-ICAM |
Synonyms: | ICAM2, CD102, ICAM-2, CD102 antigen |
Target Sequences: | NM_000873 NP_000864.2 P13598 |
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