Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene Name: | inhibitor of Bruton agammaglobulinemia tyrosine kinase |
Synonyms: | IBTK, BTBD26, BTKI, BTK-binding protein, KIAA1417, RP1-93K22.1, DKFZP564B116 |
Target Sequences: | AL050018 CAB43239.1 Q9P2D0 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.