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IBSP / Bone Sialoprotein is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
Gene Name: | integrin-binding sialoprotein |
Synonyms: | IBSP, Bone Sialoprotein, Bone sialoprotein II, BSP, BSP II, Cell-binding sialoprotein, BNSP, Bone Sialprotein II, Integrin-binding sialoprotein, Bone sialoprotein 2, BSP-II, SP-II |
Target Sequences: | NM_004967 NP_004958.2 P21815 |
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