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IAPP / Amylin

islet amyloid polypeptide

IAPP / Amylin is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity.

Gene Name: islet amyloid polypeptide
Synonyms: IAPP, Diabetes-associated peptide, Islet amyloid polypeptide, AMYLIN, IAP, Insulinoma amyloid peptide
Target Sequences: NM_000415 NP_000406.1 P10997

Publications (6)

1
Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD, Despa F. Journal of the American Heart Association. 2014 3: (WB; Human) [Full Text Article] [PubMed:25146704] [PMC:PMC4310392] Related Antibodies: LS-C20521.
2
Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation. Ribeiro D, Horvath I, Heath N, Hicks R, Forslöw A, Wittung-Stafshede P. Proceedings of the National Academy of Sciences of the United States of America. 2017 October;114:11127-11132. [Full Text Article] [PubMed:28973954] [PMC:PMC5651775]
3
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins. Pietro Sormanni, Francesco A Aprile, Michele Vendruscolo. Proceedings of the National Academy of Sciences of the United States of America. 2015 August;112:9902-7. [Full Text Article] [PubMed:26216991] [PMC:PMC4538631] Related Antibodies: LS-B35.
4
Melatonin influences the expression and oligomerization of amylin in rat INS-1E cells. E-M Jung, Y-M Yoo, E-B Jeung. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2019 October;70: [Full Text Article] [PubMed:31889041] Related Antibodies: LS-C352341.
5
Human Islet Amyloid Polypeptide Overexpression in INS-1E Cells Influences Amylin Oligomerization under ER Stress and Oxidative Stress. Yeong-Min Yoo, Seong Soo Joo. International journal of molecular sciences. 2021 Oct;22:11341. [Full Text Article] [PubMed:34768769] [PMC:PMC8583535] Related Antibodies: LS-C352341.
6
Amylin deposition in the brain: A second amyloid in Alzheimer disease?. Jackson K, Barisone GA, Diaz E, Jin LW, DeCarli C, Despa F. Annals of neurology. 2013 Oct;74:517-26. [Full Text Article] [PubMed:23794448] [PMC:PMC3818462] Related Antibodies: LS-C20521.
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ELISA Kits (24)
Cell-Based (1)
Competitive EIA (17)
Custom (3)
Sandwich (3)
IAPP / Amylin (24)
Human (8)
Mouse (7)
Rat (4)
Chicken (1)
Dog (1)
Monkey (1)
Rabbit (1)
96-Well Microplate (1)
96-Well Strip Plate (23)
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Yes (1)
Adherent Cell Cultures (1)
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Cell Lysates (2)
Plasma (17)
Serum (17)
Tissue Homogenates (6)
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IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
6.17 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
6.17 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
IAPP / Amylin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
6.17 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
IAPP / Amylin ELISA Kit
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Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
IAPP / Amylin ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
IAPP / Amylin ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
IAPP / Amylin ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IAPP / Amylin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
25 - 1600 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,002
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Chicken
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Monkey
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rabbit
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
IAPP / Amylin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
47 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$968
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
25 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
IAPP / Amylin ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
IAPP / Amylin ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
25 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
25 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).