HYOU1 / ORP150

hypoxia up-regulated 1

HYOU1 / ORP150 belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants.

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Proteins (8)

Type

Recombinant (8)

Target

HYOU1 / ORP150 (8)

Publications

No (8)

Tag

10His, C-terminus (2)

6His, N-terminus (1)

GST (2)

GST, N-terminus (1)

His (2)

Species

Human (8)

Source

E. coli (2)

Human Cells (2)

Mammalian Cells (1)

Wheat Germ Extract (3)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (3)

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Human HYOU1 / ORP150 Protein (Recombinant 10His, C-terminus) (Met695-Leu999) - LS-G40342

Source:

Human Cells

Tag:

10His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

36kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human HYOU1 / ORP150 Protein (Recombinant GST) (Full Length) - LS-G32200

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

38.06 kDa

Price:

10 µg/$479; 25 µg/$670

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Human HYOU1 / ORP150 Protein (Recombinant GST) (Full Length) - LS-G32203

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

41.91 kDa

Price:

10 µg/$479; 25 µg/$670

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Human HYOU1 / ORP150 Protein (Recombinant GST, N-terminus) (aa901-999) - LS-G61548

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human HYOU1 / ORP150 Protein (Recombinant 6His, N-terminus) (Val35-Leu147) - LS-G96962

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

14 kDa

Price:

10 µg/$265; 100 µg/$365; 200 µg/$484; 50 µg/$315

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Human HYOU1 / ORP150 Protein (Recombinant 10His, C-terminus) (Met695-Leu999) - LS-G139606

Source:

Mammalian Cells

Tag:

10His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

36 kDa

Price:

10 µg/$288; 50 µg/$436

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Human HYOU1 / ORP150 Protein (Recombinant His) (Met695-Leu994) - LS-G97545

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

35.2 kDa

Price:

50 µg/$721

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Human HYOU1 / ORP150 Protein (Recombinant His) (aa695-994) - LS-G14973

Source:

E. coli

Tag:

His

Molecular Weight:

35.3 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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