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tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.
Gene Name: | tRNA-yW synthesizing protein 5 |
Synonyms: | TYW5, C2orf60, HTYW5, TRNA-yW synthesizing protein 5, TRNA yW-synthesizing enzyme 5 |
Target Sequences: | A2RUC4 A2RUC4 |
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