HTRA1

HtrA serine peptidase 1

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

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Products

Antibodies (50)

ELISA Kits (12)

Proteins (10)

Type

Custom (1)

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Primary (50)

Recombinant (6)

Sandwich (9)

Sandwich CLIA (2)

Target

HTRA1 (72)

Reactivity

Human (55)

Mouse (14)

Rat (6)

Bovine (4)

Chicken (1)

Chimpanzee (3)

Dog (1)

E. coli (16)

Gibbon (3)

Monkey (4)

Pig (3)

Porcine (1)

Rabbit (1)

Sheep (1)

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Application

IHC (16)

IHC-P (4)

WB (50)

ELISA (12)

ICC (1)

IF (8)

Peptide-ELISA (1)

Host

rabbit (50)

Isotype

IgG (17)

Clonality

polyclonal pc (50)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (10)

APC (3)

APC Conjugated (5)

Azide-free (2)

Biotin Conjugated (6)

Cy3 Conjugated (3)

Cy7 Conjugated (3)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (5)

Unconjugated (16)

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Epitope

aa10-146 (8)

aa204-364 (8)

aa304-442 (8)

aa116-147 (7)

aa381-412 (7)

aa122-171 (4)

aa234-249 (2)

Publications

No (70)

Yes (2)

Sample Type

Plasma (7)

Serum (7)

Tissue Homogenates (1)

Tag

6His, N-terminus (2)

6His-SUMO, N-terminus (1)

His (2)

His-GST (1)

Myc-DDK (Flag) (3)

Myc-DDK (Flag), C-terminus (1)

Species

E. coli (2)

Human (5)

Mouse (2)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (5)

Purification

Purified (1)

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HTRA1 Antibody (aa381-412) LS-C98879

(4.0) Rating

(1) Publication(s)

Antibody:

HTRA1 Rabbit anti-Human Polyclonal (aa381-412) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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HTRA1 Antibody (aa116-147) LS-C98878

Antibody:

HTRA1 Rabbit anti-Human Polyclonal (aa116-147) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$393

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HTRA1 Antibody (aa122-171) LS-C146185

Antibody:

HTRA1 Rabbit anti-Human Polyclonal (aa122-171) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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Human HTRA1 (Sandwich ELISA) ELISA Kit - LS-F11673

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human HTRA1 (Sandwich ELISA) ELISA Kit - LS-F6692

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$792

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Human HTRA1 (CLIA) ELISA Kit - LS-F26361

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

8.23 - 6000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$851

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Mouse HTRA1 Protein (Over-Expression Lysate 6His, N-terminus) (Leu23-Pro480) - LS-G26674

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

49 kDa

Price:

100 µg/$298

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Mouse HTRA1 Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Leu23-Pro480) - LS-G26823

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

49 kDa

Price:

200 µl/$283

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Human HTRA1 Protein (Recombinant 6His-SUMO, N-terminus) (aa23-480) - LS-G56837

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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HTRA1 Antibody (aa234-249) LS-C190914

Antibody:

HTRA1 Rabbit anti-Human Polyclonal (aa234-249) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$634

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Human HTRA1 Protein (Recombinant His-GST) (aa204-364) - LS-G16145

Source:

E. coli

Tag:

His-GST

Molecular Weight:

49.1 kDa

Price:

10 µg/$299; 50 µg/$552; 100 µg/$882; 200 µg/$1,080; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$3,851; 2 mg/$2,453

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Human HTRA1 (Sandwich ELISA) ELISA Kit - LS-F21937

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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HTRA1 Antibody LS-C781555

Antibody:

HTRA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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HTRA1 Antibody (aa204-364) LS-C294536

Antibody:

HTRA1 Rabbit anti-Human Polyclonal (aa204-364) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$597; 2 ml/$826; 5 ml/$1,352

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HTRA1 Antibody (aa204-364, Biotin) LS-C297382

Antibody:

HTRA1 Rabbit anti-Human Polyclonal (aa204-364) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$329; 200 µl/$381; 500 µl/$550; 1 ml/$654; 2 ml/$890; 5 ml/$1,487

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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Human HTRA1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67943

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49 kDa

Price:

20 µg/$1,107

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E. coli HTRA1 Protein (Recombinant His) (aa10-146) - LS-G16140

Source:

E. coli

Tag:

His

Molecular Weight:

15.7 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Monkey HTRA1 (Sandwich ELISA) ELISA Kit - LS-F44887

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Human HTRA1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81038

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.53 kDa

Price:

20 µg/$215

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HTRA1 Antibody (aa116-147) LS-C327589

Antibody:

HTRA1 Rabbit anti-Human Polyclonal (aa116-147) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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HTRA1 Antibody (aa116-147, Biotin) LS-C278267

Antibody:

HTRA1 Rabbit anti-Human Polyclonal (aa116-147) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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HTRA1 Antibody (aa116-147, FITC) LS-C278268

Antibody:

HTRA1 Rabbit anti-Human Polyclonal (aa116-147) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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HTRA1 Antibody (aa116-147, APC) LS-C278266

Antibody:

HTRA1 Rabbit anti-Human Polyclonal (aa116-147) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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HTRA1 Antibody (aa116-147, PE) LS-C278270

Antibody:

HTRA1 Rabbit anti-Human Polyclonal (aa116-147) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

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HTRA1 Antibody (aa116-147, Azide-free, HRP) LS-C278269

Antibody:

HTRA1 Rabbit anti-Human Polyclonal (aa116-147) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

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