HTR2C / 5-HT2C Receptor

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.

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ELISA Kits (5)

Type

Custom (2)

Sandwich (3)

Target

HTR2C / 5-HT2C Receptor (5)

Reactivity

Human (1)

Mouse (1)

Rat (2)

Dog (1)

Format

96-Well Strip Plate (5)

Publications

No (5)

Sample Type

Plasma (2)

Serum (2)

Tissue Homogenates (1)

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Rat HTR2C / 5-HT2C Receptor (Sandwich ELISA) ELISA Kit - LS-F7038

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$783

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Human HTR2C / 5-HT2C Receptor (Sandwich ELISA) ELISA Kit - LS-F66681

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Rat HTR2C / 5-HT2C Receptor (Sandwich ELISA) ELISA Kit - LS-F66735

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

Mouse HTR2C / 5-HT2C Receptor (Custom) ELISA Kit - LS-F65833

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$669

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Dog HTR2C / 5-HT2C Receptor (Custom) ELISA Kit - LS-F66301

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Dog

Price:

1 Plate/$783

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