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HTR2C / 5-HT2C Receptor
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.
| Gene Name: | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled |
| Family/Subfamily: | GPCR , Serotonin |
| Synonyms: | HTR2C, 5-HT-1C, 5-HT1c receptor, 5HT-1C, 5-HT2C, 5-HT2c receptor, 5HT2C Receptor, 5-HT-2C, 5-HT1C, 5-HTR2C, HTR1C, Serotonin 5-HT-1c receptor, Serotonin receptor 2C, Serotonin 1c receptor, Serotonin 5-HT-2C receptor, Serotonin 2c receptor |
| Target Sequences: | nm_000868 NP_000859.1 P28335 |
Publications (3)
1
Human polyomavirus receptor distribution in brain parenchyma contrasts with receptor distribution in kidney and choroid plexus. Haley SA, O'Hara BA, Nelson CD, Brittingham FL, Henriksen KJ, Stopa EG, Atwood WJ. The American journal of pathology. 2015 August;185:2246-58. (Human)
[Full Text Article]
[PubMed:26056932]
[PMC:PMC4530127]
Related Antibodies: LS-A1119.
2
Effects of Jian-Pi-Zhi-Dong Decoction on the Expression of 5-HT and Its Receptor in a Rat Model of Tourette Syndrome and Comorbid Anxiety. Dan Wang, Hui-Ling Tian, Xia Cui, Qian Wang, Fan Guo, Wen Zhang, Qi-Sheng Tang. Medical science monitor : international medical journal of experimental and clinical research. 2020 August;26:e924658. [Full Text Article]
[PubMed:32738135]
[PMC:PMC7416613]
Related Antibodies: LS-B11334.
3
Functional constipation induces bladder overactivity associated with upregulations of Htr2 and Trpv2 pathways. Nao Iguchi, Alonso Carrasco Jr, Alison X Xie, Ricardo H Pineda, Anna P Malykhina, Duncan T Wilcox. Scientific reports. 2021 January;11:1149. [Full Text Article]
[PubMed:33441874]
[PMC:PMC7806916]
Related Antibodies: LS-C386171.
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HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (aa400-450) Antibody
Mouse, Rat, Human
IF, IHC-P, WB
Unconjugated
50 µl/$460
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (130-210 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (aa161-210) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
Fast Shipping
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC-P, WB
Unconjugated
100 µl/$412
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
HTR2C / 5-HT2C Receptor Mouse anti-Human Monoclonal (12K175) Antibody
Human
Flo, IHC
Unconjugated
100 µg/$884
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC-P
Unconjugated
100 µg/$357
HTR2C / 5-HT2C Receptor Rabbit-New Zealand White anti-Mouse Polyclonal (aa420-460) Antibody
Mouse, Rat
IHC, WB
Unconjugated
100 µl/$393
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (Pro190) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
HTR2C / 5-HT2C Receptor Mouse anti-Human Monoclonal (1A8) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (aa253-282) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (aa253-282) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (aa253-282) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (aa253-282) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (aa253-282) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
HTR2C / 5-HT2C Receptor Rabbit anti-Rat Polyclonal (aa439-460) Antibody
Mouse, Rat
IHC, WB
Unconjugated
100 µl/$890
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (aa388-437) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (aa395-444) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal (aa274-308) Antibody
Human
Peptide-ELISA, WB
Unconjugated
400 µl/$393
HTR2C / 5-HT2C Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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