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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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HTR2B / 5-HT2B Receptor
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.
| Gene Name: | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled |
| Family/Subfamily: | GPCR , Serotonin |
| Synonyms: | HTR2B, 5-HT 2B receptor, 5HT2B Receptor, 5-HT(2B), 5-HT-2B, 5-HT2b receptor, 5-HT2B, Serotonin 2b receptor, Serotonin 5-HT-2b receptor, Serotonin receptor 2B |
| Target Sequences: | NM_000867 NP_000858.3 P41595 |
Publications (1)
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