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G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
Gene Name: | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled |
Family/Subfamily: | GPCR , Serotonin |
Synonyms: | HTR2A, 5-HT2A, 5-HT-2A, 5-HT2a receptor, 5HT2A Receptor, 5-HT-2, 5-HT2A/2C, 5-HT2A/2C receptor, 5-HT2 receptor, HTR2, Serotonin 5-HT-2A receptor, Serotonin receptor 2A, Serotonin 2a receptor |
Target Sequences: | NM_000621 NP_000612.1 P28223 |
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