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G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
Gene Name: | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
Family/Subfamily: | GPCR , Serotonin |
Synonyms: | HTR1D, 5-HT1d alpha receptor, 5HT1D Receptor, 5-HT1d-type serotonin receptor, 5-HT1D, 5-HT-1D, 5-HT-1D-alpha, 5-HT1d receptor, HT1d receptor, HTR1DA, HTRL, HT1DA, Serotonin receptor 1D, RDC4, Gpcr14, Serotonin 1d receptor, Serotonin 5-HT-1d receptor |
Target Sequences: | NM_000864 NP_000855.1 P28221 |
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