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HTR1A / 5-HT1A Receptor
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
| Gene Name: | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled |
| Family/Subfamily: | GPCR , Serotonin |
| Synonyms: | HTR1A, 5-HT-1A, 5HT1a, 5-HT1a receptor, 5HT1ar, 5HT1A receptor, 5-HT1A, ADRBRL1, ADRB2RL1, PFMCD, Serotonin 5-HT-1a receptor, Serotonin type 1a receptor, Serotonergic type 1A receptor, G-21, Serotonin 1a receptor, Serotonin receptor 1A |
| Target Sequences: | NM_000524 NP_000515.2 P08908 |
Publications (2)
1
Spatial cluster analysis of nanoscopically mapped serotonin receptors for classification of fixed brain tissue. Sams M, Silye R, Göhring J, Muresan L, Schilcher K, Jacak J. Journal of biomedical optics. 2014 19:11021. (IHC; Human)
[Full Text Article]
[PubMed:24297043]
Related Antibodies: LS-B970.
2
Expression of serotonin receptors in human hepatocellular cancer. Soll C, Riener MO, Oberkofler CE, Hellerbrand C, Wild PJ, DeOliveira ML, Clavien PA. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 Nov;18:5902-10. [Full Text Article]
[PubMed:23087410]
Related Antibodies: LS-B970.
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HTR1A / 5-HT1A Receptor
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Cancer
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Human, Orangutan, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Human, Orangutan, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Human, Orangutan, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
Cancer
HTR1A / 5-HT1A Receptor Mouse anti-Rat Monoclonal (19A9.2) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$765
HTR1A / 5-HT1A Receptor Rabbit anti-Rat Polyclonal (aa294-312) Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
100 µl/$856
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 120 µl/$355; 200 µl/$450
HTR1A / 5-HT1A Receptor Goat anti-Mouse Polyclonal (aa322-334) Antibody
Mouse
Peptide-ELISA, WB
Unconjugated
100 µg/$503
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal (aa404-422) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal (260-340 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
HTR1A / 5-HT1A Receptor Rabbit anti-Rat Polyclonal (Internal) Antibody
Rat
ELISA, IHC-P, WB
Unconjugated
100 µl/$485
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Human, Orangutan, Gibbon
WB
Biotin Conjugated
100 µl/$442
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Human, Orangutan, Gibbon
WB
FITC Conjugated
100 µl/$442
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µg/$305; 100 µg/$357
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC-P, WB
Unconjugated
60 µl/$460
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal (aa239-273) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal (aa291-340) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µg/$305; 100 µg/$357
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Rat, Human
WB
Unconjugated
100 µl/$299
HTR1A / 5-HT1A Receptor Rabbit anti-Human Polyclonal Antibody
Rat, Human
WB
Unconjugated
100 µl/$386
HTR1A / 5-HT1A Receptor Goat anti-Human Polyclonal (aa249-262) Antibody
Human
Peptide-ELISA
Unconjugated
100 µg/$401
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