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In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity). Positive regulator of PARK2 translocation to damaged mitochondria.
Gene Name: | heat shock 70kDa protein 1-like |
Synonyms: | HSPA1L, Heat shock 70 kDa protein 1L, Heat shock 70kD protein-like 1, HSP70T, HSP70-HOM, HSP70-1L, Hum70t, Heat shock 70 kd protein 1-hom |
Target Sequences: | NM_005527 NP_005518.3 P34931 |
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