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In mammalian cells, there are two or more genes encoding cytosolic Hsp90 homologues, with the human Hsp90 alpha showing 85% sequence identity to Hsp90 beta. The alpha- and the beta-forms are thought to be the result of a gene duplication event that occurred millions of years ago. In humans there are three HSP90 alpha genes, HSP90AA1 and HSP90AA2, which are inducible, and HSP90AB, which is constitutively expressed. HSP90 alpha is located in the cytosol.
Target Name: | HSP90 Alpha (HSP90AA) |
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