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HSP70 / Heat Shock Protein 70

The 70 kilodalton heat shock proteins (Hsp70s) are a family of conserved ubiquitously expressed heat shock proteins. Proteins with similar structure exist in virtually all living organisms. The Hsp70s are an important part of the cell's machinery for protein folding, and help to protect cells from stress. Members of the Hsp70 family are strongly upregulated by heat stress and toxic chemicals, particularly heavy metals such as arsenic, cadmium, copper, mercury, etc. Hsp70 was originally discovered by FM Ritossa in the 1960s when a lab worker accidentally boosted the incubation temperature of Drosophila (fruit flies). When examining the chromosomes, Ritossa found a "puffing pattern" that indicated the elevated gene transcription of an unknown protein. This was later described as the "Heat Shock Response" and the proteins were termed the "Heat Shock Proteins" (Hsps). Hsp70 is also know as Hsp72.

HSP70 / Heat Shock Protein 70 Target Details

Target Name: HSP70 / Heat Shock Protein 70
Target Abbreviation: HSP70

Publications (4)

1
Sodium butyrate upregulates expression of NKG2D ligand MICA/B in HeLa and HepG2 cell lines and increases their susceptibility to NK lysis. Zhang C, Wang Y, Zhou Z, Zhang J, Tian Z. Cancer immunology, immunotherapy : CII. 2009 58:1275-85. (WB) [PubMed:19139882]
2
Presence of diabetes autoantigens in extracellular vesicles derived from human islets. Hasilo CP, Negi S, Allaeys I, Cloutier N, Rutman AK, Gasparrini M, Bonneil É, Thibault P, Boilard É, Paraskevas S. Scientific reports. 2017 7:5000. (ICC, WB, Flo; Human, Hamster) [Full Text Article] [PubMed:28694505] [PMC:PMC5504025] Related Antibodies: LS-C231813.
3
Selenium Nanoparticles Pre-Treatment Reverse Behavioral, Oxidative Damage, Neuronal Loss and Neurochemical Alterations in Pentylenetetrazole-Induced Epileptic Seizures in Mice. Xiaona Yuan, Zhenshuai Fu, Pengfei Ji, Lubo Guo, Ali O Al-Ghamdy, Ali Alkandiri, Ola A Habotta, Ahmed E Abdel Moneim, Rami B Kassab. International journal of nanomedicine. 2020 September;15:6339-6353. [Full Text Article] [PubMed:32922005] [PMC:PMC7455605]
4
CXCR4 regulates Plasmodium development in mouse and human hepatocytes. Hironori Bando, Ariel Pradipta, Shiroh Iwanaga, Toru Okamoto, Daisuke Okuzaki, Shun Tanaka, Joel Vega-Rodríguez, Youngae Lee, Ji Su Ma, Naoya Sakaguchi, Akira Soga, Shinya Fukumoto, Miwa Sasai, Yoshiharu Matsuura, Masao Yuda, Marcelo Jacobs-Lorena, Masahiro Yamamoto. The Journal of experimental medicine. 2019 Aug;216:1733-1748. [Full Text Article] [PubMed:31189656] [PMC:PMC6683982] Related Antibodies: LS-C109068.
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HSP70 / Heat Shock Protein 70 (21)
Human (5)
Mouse (5)
Rat (3)
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Chicken (3)
Goat (1)
Monkey (1)
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12 x 8-Well Microstrips (3)
96-Well Microplate (3)
96-Well Strip Plate (15)
No (20)
Yes (1)
Cell Culture Supernatants (4)
Cell Lysates (4)
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Serum (21)
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HSP70 / Heat Shock Protein 70 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
HSP70 / Heat Shock Protein 70 ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HSP70 / Heat Shock Protein 70 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HSP70 / Heat Shock Protein 70 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
39.06 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
HSP70 / Heat Shock Protein 70 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
HSP70 / Heat Shock Protein 70 ELISA Kit
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Sandwich
96-Well Microplate
Chicken
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$627
HSP70 / Heat Shock Protein 70 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
HSP70 / Heat Shock Protein 70 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HSP70 / Heat Shock Protein 70 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
39.063 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HSP70 / Heat Shock Protein 70 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$627
HSP70 / Heat Shock Protein 70 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
HSP70 / Heat Shock Protein 70 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HSP70 / Heat Shock Protein 70 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HSP70 / Heat Shock Protein 70 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
HSP70 / Heat Shock Protein 70 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
0.156 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
HSP70 / Heat Shock Protein 70 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$748
HSP70 / Heat Shock Protein 70 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Goat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HSP70 / Heat Shock Protein 70 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
HSP70 / Heat Shock Protein 70 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Human
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
HSP70 / Heat Shock Protein 70 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
HSP70 / Heat Shock Protein 70 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).