HSD2 / HSD11B2

hydroxysteroid (11-beta) dehydrogenase 2

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

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Products

ELISA Kits (6)

Type

Custom (1)

Sandwich (5)

Target

HSD2 / HSD11B2 (6)

Reactivity

Human (2)

Mouse (1)

Rat (2)

Bovine (1)

Format

96-Well Strip Plate (6)

Publications

No (6)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (2)

Plasma (2)

Saliva (1)

Serum (2)

Tissue Homogenates (3)

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Human HSD2 / HSD11B2 (Sandwich ELISA) ELISA Kit - LS-F8771

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Saliva, Tissue Homogenates

Price:

1 Plate/$730

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Mouse HSD2 / HSD11B2 (Sandwich ELISA) ELISA Kit - LS-F66122

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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Rat HSD2 / HSD11B2 (Sandwich ELISA) ELISA Kit - LS-F9758

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$783

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Human HSD2 / HSD11B2 (Sandwich ELISA) ELISA Kit - LS-F65244

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Price:

1 Plate/$669

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Bovine HSD2 / HSD11B2 (Custom) ELISA Kit - LS-F65478

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Bovine

Price:

1 Plate/$669

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Rat HSD2 / HSD11B2 (Sandwich ELISA) ELISA Kit - LS-F67090

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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