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Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
Gene Name: | Heparan Sulfate (GLUCOSAMINE) 3-o-sulfotransferase 3a1 |
Synonyms: | HS3ST3A1, 30ST3A1, 3-OST-3A, 3OST3A1, H3-OST-3A, HS3ST3A |
Target Sequences: | NM_006042 NP_006033.1 Q9Y663 |
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