HRG

histidine-rich glycoprotein

Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis.

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Products

Proteins (13)

Type

Over-Expression Lysate (2)

Recombinant (10)

Target

HRG (13)

Publications

No (13)

Tag

10His, C-terminus (1)

GST (1)

His, N-Terminal (3)

His,C-terminus (1)

His-GST (2)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (9)

Mouse (1)

Rat (2)

Source

293F Cells (3)

293T Cells (1)

CHO Cells (1)

E. coli (3)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (6)

Low Endotoxin Level

Low endotoxin level (2)

Biologically Active

Biologically active (2)

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Human HRG Protein (Recombinant GST) (Full Length) - LS-G28919

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

86 kDa

Price:

2 µg/$439

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Human HRG Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65915

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.6 kDa

Price:

20 µg/$1,107

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Human HRG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76518

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.52 kDa

Price:

20 µg/$150

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HRG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123202

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.52 kDa

Price:

100 µg/$494

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Human HRG Protein (Recombinant His, N-Terminal) (Val19-Lys525) - LS-G133592

Source:

293F Cells

Tag:

His, N-Terminal

Molecular Weight:

80kDa

Price:

10 µg/$315; 50 µg/$652; 200 µg/$1,228; 100 µg/$1,034; 1 mg/$2,469; 500 µg/$1,971; 5 mg/$4,551; 2 mg/$2,661

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Human HRG Protein (Recombinant) - LS-G133772

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

57.7 kDa

Price:

5 µg/$268; 25 µg/$349

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Human HRG Protein (Recombinant His, N-Terminal) - LS-G132777

Source:

293F Cells

Tag:

His, N-Terminal

Molecular Weight:

75kDa

Price:

10 µg/$295; 50 µg/$530; 200 µg/$1,045; 100 µg/$847; 1 mg/$2,211; 500 µg/$1,728; 5 mg/$3,697; 2 mg/$2,402

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Rat HRG Protein (Recombinant His, N-Terminal) (Leu19-Lys525) - LS-G132943

Source:

293F Cells

Tag:

His, N-Terminal

Molecular Weight:

75kDa

Price:

10 µg/$332; 50 µg/$762; 200 µg/$1,378; 100 µg/$1,167; 1 mg/$2,664; 500 µg/$2,160; 5 mg/$5,321; 2 mg/$2,839

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Human HRG Protein (10His, C-terminus) (Met1-Lys525) - LS-G48742

Source:

HEK 293 Cells

Tag:

10His, C-terminus

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$480

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Human HRG Protein (Recombinant His,C-terminus) (Met1-Lys525) - LS-G138297

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

59 kDa

Price:

100 µg/$843

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Mouse HRG Protein (Recombinant His-GST) (aa93-328) - LS-G14968

Source:

E. coli

Tag:

His-GST

Molecular Weight:

55.4 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Human HRG Protein (Recombinant His-GST) (aa18-254) - LS-G14967

Source:

E. coli

Tag:

His-GST

Molecular Weight:

59.2 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Rat HRG Protein (Recombinant His-T7) (aa106-302) - LS-G14971

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.2 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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