HRG

histidine-rich glycoprotein

Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis.

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Products

ELISA Kits (18)

Type

Custom (1)

Sandwich (16)

Sandwich CLIA (1)

Target

HRG (18)

Reactivity

Human (6)

Mouse (4)

Rat (2)

Chicken (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Sheep (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (14)

Publications

No (18)

Sample Type

Cell Culture Supernatants (3)

EDTA Plasma (2)

Heparin Plasma (2)

Plasma (10)

Serum (11)

Tissue Homogenates (3)

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Mouse HRG (Sandwich ELISA) ELISA Kit - LS-F13230

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Rat HRG (Sandwich ELISA) ELISA Kit - LS-F19634

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

3.12 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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Human HRG (Sandwich ELISA) ELISA Kit - LS-F7563

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.469 - 30 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$730

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Rat HRG (Sandwich ELISA) ELISA Kit - LS-F9061

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human HRG (Sandwich ELISA) ELISA Kit - LS-F11662

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human HRG (Sandwich ELISA) ELISA Kit - LS-F20923

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Mouse HRG (Sandwich ELISA) ELISA Kit - LS-F6589

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

3.13 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma

Price:

1 Plate/$748

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Bovine HRG (Custom ELISA) ELISA Kit - LS-F19635

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Human HRG (CLIA) ELISA Kit - LS-F29374

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Human HRG (Sandwich ELISA) ELISA Kit - LS-F34716

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse HRG (Sandwich ELISA) ELISA Kit - LS-F34717

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Monkey HRG (Sandwich ELISA) ELISA Kit - LS-F44876

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Porcine HRG (Sandwich ELISA) ELISA Kit - LS-F44877

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Chicken HRG (Sandwich ELISA) ELISA Kit - LS-F44878

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Rabbit HRG (Sandwich ELISA) ELISA Kit - LS-F44879

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Sheep HRG (Sandwich ELISA) ELISA Kit - LS-F44880

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$691

Select

Mouse HRG (Sandwich ELISA) ELISA Kit - LS-F57300

Type:

Sandwich

Reactivity:

Mouse

Range:

156 - 10000 pg/ml

Sample Types:

Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum

Price:

1 Plate/$699

Select

Human HRG (Sandwich ELISA) ELISA Kit - LS-F57297

Type:

Sandwich

Reactivity:

Human

Range:

156 - 10000 pg/ml

Sample Types:

Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum

Price:

1 Plate/$699

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