HRG

histidine-rich glycoprotein

Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis.

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Products

Antibodies (52)

Type

Primary (52)

Target

HRG (52)

Reactivity

Human (34)

Mouse (19)

Rat (11)

Pig (8)

Rabbit (2)

Application

IHC (10)

IHC-P (7)

WB (43)

ELISA (9)

ICC (1)

IP (2)

Host

rabbit (48)

mouse (4)

Product Group

IHCPlus (1)

Isotype

IgG (18)

IgG1 (1)

Clonality

monoclonal mc (3)

polyclonal pc (49)

Clone

23 (1)

Format

APC (3)

APC Conjugated (4)

Biotin Conjugated (5)

Cy3 Conjugated (3)

Cy7 Conjugated (3)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (4)

Preservative Free (1)

Unconjugated (23)

Epitope

aa106-302 (8)

aa18-254 (8)

aa93-328 (8)

C-Terminus (4)

aa13-42 (1)

aa19-200 (1)

aa287-336 (1)

Publications

No (52)

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HRG Antibody (aa13-42) LS-C100915

Antibody:

HRG Rabbit anti-Human Polyclonal (aa13-42) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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HRG Antibody (C-Terminus) LS-B11467

Antibody:

HRG Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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HRG Antibody (C-Terminus, HRP) LS-C442116

Antibody:

HRG Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Rabbit, Human

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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HRG Antibody (C-Terminus, Biotin) LS-C442096

Antibody:

HRG Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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HRG Antibody (C-Terminus, FITC) LS-C442115

Antibody:

HRG Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Rabbit, Human

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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HRG Antibody LS-C409966

Antibody:

HRG Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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HRG Antibody (aa18-254) LS-C294512

Antibody:

HRG Rabbit anti-Human Polyclonal (aa18-254) Antibody

Reactivity:

Mouse, Pig, Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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HRG Antibody LS-C310612

Antibody:

HRG Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$749

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HRG Antibody (aa19-200) LS-C344071

Antibody:

HRG Rabbit anti-Human Polyclonal (aa19-200) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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HRG Antibody LS-C767305

Antibody:

HRG Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Rat

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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HRG Antibody LS-C667842

Antibody:

HRG Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

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HRG Antibody LS-C406454

Antibody:

HRG Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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HRG Antibody LS-C403217

Antibody:

HRG Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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HRG Antibody LS-C780867

Antibody:

HRG Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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HRG Antibody LS-C487015

Antibody:

HRG Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

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HRG Antibody LS-C487017

Antibody:

HRG Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

20 µl/$256; 100 µl/$412

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HRG Antibody (clone 23, Preservative Free) LS-C819942

Antibody:

HRG Mouse anti-Human Monoclonal (Preservative Free) (23) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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HRG Antibody (aa93-328) LS-C294516

Antibody:

HRG Rabbit anti-Mouse Polyclonal (aa93-328) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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HRG Antibody (aa93-328, Biotin) LS-C299452

Antibody:

HRG Rabbit anti-Mouse Polyclonal (aa93-328) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387

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HRG Antibody (aa93-328, FITC) LS-C304452

Antibody:

HRG Rabbit anti-Mouse Polyclonal (aa93-328) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765

• Unconjugated
• Biotin
• FITC

• Unconjugated
• Biotin
• FITC

Select

HRG Antibody LS-C487016

Antibody:

HRG Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

Select

HRG Antibody LS-C487018

Antibody:

HRG Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

Select

HRG Antibody LS-C487019

Antibody:

HRG Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$375; 200 µl/$473; 400 µl/$648

Select

HRG Antibody LS-C310613

Antibody:

HRG Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

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HRG Antibody (aa287-336) LS-C107611

Antibody:

HRG Rabbit anti-Human Polyclonal (aa287-336) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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