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HP / Haptoglobin
haptoglobin
HP / Haptoglobin is a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | haptoglobin |
| Synonyms: | HP, Binding peptide, Haptoglobin alpha(1S)-beta, Haptoglobin, beta polypeptide, Haptoglobin, Haptoglobin alpha(2FS)-beta, Haptoglobin, alpha polypeptide, HP2ALPHA2, BP, Zonulin, HPA1S |
| Target Sequences: | NM_005143 NP_005134.1 P00738 |
Publications (7)
1
Randomized, controlled trial evaluating the effect of multi-strain probiotic on the mucosal microbiota in canine idiopathic inflammatory bowel disease. White R, Atherly T, Guard B, Rossi G, Wang C, Mosher C, Webb C, Hill S, Ackermann M, Sciabarra P, Allenspach K, Suchodolski J, Jergens AE. Gut microbes. 2017 September;8:451-466. [Full Text Article]
[PubMed:28678609]
[PMC:PMC5628651]
Related Antibodies: LS-C132998.
2
Glucocorticoid and dietary effects on mucosal microbiota in canine inflammatory bowel disease. Atherly T, Rossi G, White R, Seo YJ, Wang C, Ackermann M, Breuer M, Allenspach K, Mochel JP, Jergens AE. PloS one. 2019 December;14:e0226780. [Full Text Article]
[PubMed:31887117]
[PMC:PMC6936794]
Related Antibodies: LS-C132998.
3
Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia. Isabelle S Massart, Geneviève Paulissen, Audrey Loumaye, Pascale Lause, Sarah A Pötgens, Morgane M Thibaut, Estelle Balan, Louise Deldicque, Azeddine Atfi, Edouard Louis, Damien Gruson, Laure B Bindels, Marie-Alice Meuwis, Jean-Paul Thissen. Cancers. 2020 October;12: [Full Text Article]
[PubMed:33142864]
[PMC:PMC7693727]
Related Antibodies: LS-C404051.
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HP / Haptoglobin
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Publications
No
(194)
Yes
(3)
Cancer
HP / Haptoglobin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$775
Cancer
HP / Haptoglobin Goat anti-Human Polyclonal Antibody
Human
ELISA, Flo, ID, IHC, IHC-P, IP, WB
Unconjugated
0.5 mg/$460
HP / Haptoglobin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$478; 100 µl/$914
HP / Haptoglobin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
HP / Haptoglobin Goat anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
1 mg/$622
HP / Haptoglobin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HP / Haptoglobin Rabbit anti-Human Polyclonal (aa296-322) (APC) Antibody
Human
FLISA, Flo, IF, IHC, WB
APC Conjugated
200 µl/$952
HP / Haptoglobin Mouse anti-Human Monoclonal (26E11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
HP / Haptoglobin Rabbit anti-Human Polyclonal (aa287-336) Antibody
Human
WB
Unconjugated
100 µl/$424
HP / Haptoglobin Mouse anti-Human Monoclonal (OTI4C2) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
Cancer
HP / Haptoglobin Rabbit anti-Human Polyclonal (aa295-322) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$440
Cancer
HP / Haptoglobin Mouse anti-Human Monoclonal (aa19-406) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$440
HP / Haptoglobin Goat anti-Human Polyclonal (aa51-63) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
HP / Haptoglobin Mouse anti-Human Monoclonal (OTI2B11) Antibody
WB
Unconjugated
100 µl/$434
HP / Haptoglobin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HP / Haptoglobin Guinea pig anti-Rabbit Polyclonal (aa21-98) Antibody
Rabbit
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
HP / Haptoglobin Rabbit anti-Human Polyclonal (aa 19-406) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
HP / Haptoglobin Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
HP / Haptoglobin Rabbit anti-Human Polyclonal (aa19-406) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
HP / Haptoglobin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
HP / Haptoglobin Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
HP / Haptoglobin Rabbit anti-Rat Polyclonal (Biotin) Antibody
Mouse, Rat
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
HP / Haptoglobin Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
100 µl/$585
HP / Haptoglobin Mouse anti-Human Monoclonal (UMAB10) Antibody
Human
IF, IHC, PMA, WB
Unconjugated
100 µl/$493
HP / Haptoglobin Mouse anti-Human Monoclonal (Carrier-free) (UMAB10) Antibody
Human
IF, IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
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