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HNRNPL / hnRNP L
heterogeneous nuclear ribonucleoprotein L
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogeneous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L(HNRPL) is among the proteins that are stably associated with hnRNP complexes. HNRPL along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. HNRPL is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions.~Structurally HNRPL contains 2 segments of approximately 80 amino acids each which are weakly related to each other and to the ribonucleoprotein consensus sequence-type RNA-binding domains of other hnRNP and snRNP proteins.
| Gene Name: | heterogeneous nuclear ribonucleoprotein L |
| Synonyms: | HNRNPL, HnRNP L, HnRNP-L, HNRPL, P/OKcl.14 |
| Target Sequences: | NM_001533 NP_001524.2 P14866 |
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