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HMT / HNMT
histamine N-methyltransferase
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
| Gene Name: | histamine N-methyltransferase |
| Synonyms: | HNMT, HMT, Histamine N-methyltransferase, HNMT-S1, HNMT-S2 |
| Target Sequences: | NM_006895 NP_008826.1 P50135 |
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