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HMGB3 is a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants.
Gene Name: | high mobility group box 3 |
Synonyms: | HMGB3, High mobility group protein 2a, High mobility group protein B3, HMG-2a, High mobility group box 3, High mobility group protein 4, High-mobility group box 3, HMG-4, HMG2A, HMG4 |
Target Sequences: | NM_005342 NP_005333.2 O15347 |
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