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Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4.
Gene Name: | high mobility group 20A |
Synonyms: | HMG20A, HMGXB1, High-mobility group 20A, HMG box domain containing 1, High mobility group 20A, HMG box-containing protein 20A, HMGX1 |
Target Sequences: | NM_018200 NP_060670.1 Q9NP66 |
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