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HMG1 / HMGB1

high mobility group box 1

DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.

Gene Name:	high mobility group box 1
Synonyms:	HMGB1, Amphoterin, High mobility group protein B1, High mobility group box 1, High mobility group protein 1, HMG1, HMG3, SBP-1, High-mobility group box 1, HMG-1
Target Sequences:	NM_002128 NP_002119.1 P09429

Publications (23)

Adenovirus membrane penetration activates the NLRP3 inflammasome. Barlan AU, Griffin TM, McGuire KA, Wiethoff CM. Journal of virology. 2011 85:146-55. (WB; Human) [PubMed:20980503] [PMC:PMC3014182]

Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice. Fazio EN, Dimattia GE, Chadi SA, Kernohan KD, Pin CL. BMC cell biology. 2011 12:17. (ICC, IHC; Mouse) [PubMed:21545732] [PMC:PMC3224136]

High-mobility group box 1 is essential for mitochondrial quality control. Tang D, Kang R, Livesey KM, Kroemer G, Billiar TR, Van Houten B, Zeh HJ, Lotze MT. Cell metabolism. 2011 13:701-11. (ICC, WB; Mouse) [PubMed:21641551] [PMC:PMC3293110]

SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA. Montie HL, Pestell RG, Merry DE. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:17425-36. [PubMed:22131404]

Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response. Wang W, Zhao F, Fang Y, Li X, Shen L, Cao T, Zhu H. Critical care (London, England). 2013 17:R44. (WB; Pig) [Full Text Article] [PubMed:23497622] [PMC:PMC3672474]

Cellular source and proinflammatory roles of high-mobility group box 1 in surgically injured rat vocal folds. Li-Jessen NYK, Powell M, Choi AJ, Lee BJ, Thibeault SL. The Laryngoscope. 2017 127:E193-E200. (WB; Human) [Full Text Article] [PubMed:27774594] [PMC:PMC5403630] Related Antibodies: LS-C2691.

Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap. Song W, Shen L, Wang Y, Liu Q, Goodwin TJ, Li J, Dorosheva O, Liu T, Liu R, Huang L. Nature communications. 2018 June;9:2237. [Full Text Article] [PubMed:29884866] [PMC:PMC5993831]

Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming. Frank MG, Fonken LK, Annis JL, Watkins LR, Maier SF. Brain, behavior, and immunity. 2018 March;69:62-73. [Full Text Article] [PubMed:29104062] [PMC:PMC5857401]

HMGB1 induction of clusterin creates a chemoresistant niche in human prostate tumor cells. Zhou J, Chen X, Gilvary DL, Tejera MM, Eksioglu EA, Wei S, Djeu JY. Scientific reports. 2015 October;5:15085. [Full Text Article] [PubMed:26469759] [PMC:PMC4606829]

Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. Vijayaraj P, Minasyan A, Durra A, Karumbayaram S, Mehrabi M, Aros CJ, Ahadome SD, Shia DW, Chung K, Sandlin JM, Darmawan KF, Bhatt KV, Manze CC, Paul MK, Wilkinson DC, Yan W, Clark AT, Rickabaugh TM, Wallace WD, Graeber TG, Damoiseaux R, Gomperts BN. Cell reports. 2019 December;29:3488-3505.e9. [Full Text Article] [PubMed:31825831] [PMC:PMC6927560]

Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury. Claudia Espinosa-Garcia, Fahim Atif, Seema Yousuf, Iqbal Sayeed, Gretchen N Neigh, Donald G Stein. International journal of molecular sciences. 2020 May;21: [Full Text Article] [PubMed:32466385] [PMC:PMC7312827]

Serum vitamin D receptor and High Mobility Group Box-1 (HMGB1) levels in HIV-infected patients with different immunodeficiency status: A cross-sectional study. Indah Sapta Wardani, Mochammad Hatta, Risna Halim Mubin, Agussalim Bukhari, Mulyanto, Muhammad Nasrum Massi, Irawaty Djaharuddin, Burhanuddin Bahar, Aminuddin, Siti Wahyuni. Annals of medicine and surgery (2012). 2021 March;63:102174. [Full Text Article] [PubMed:33664952] [PMC:PMC7900012]

RAGE and HMGB1 Expression in Orbital Tissue Microenvironment in Graves' Ophthalmopathy. Dominika Lacheta, Krzysztof B Poslednik, Katarzyna Czerwaty, Nils Ludwig, Marta Molinska-Glura, Ireneusz Kantor, Anna Jablonska-Pawlak, Piotr Miskiewicz, Alicja Gluszko, Zygmunt Stopa, Jacek Brzost, Miroslaw J Szczepanski. Mediators of inflammation. 2021 March;2021:8891324. [Full Text Article] [PubMed:33776579] [PMC:PMC7979288] Related Antibodies: LS-C2691.

Time course of microglia activation and brain and blood cytokine/chemokine levels following chronic ethanol exposure and protracted withdrawal in rats. Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Derek N Wills, Dennis Otero, Cindy L Ehlers, Bruno Conti. Alcohol (Fayetteville, N.Y.). 2019 May;76:37-45. [Full Text Article] [PubMed:30554034] [PMC:PMC6336521]

Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures. Matthew G Frank, Jessica L Annis, Linda R Watkins, Steven F Maier. Brain, behavior, and immunity. 2019 August;80:678-687. [Full Text Article] [PubMed:31078691] [PMC:PMC6662571]

Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages. Ludovic Boytard, Tarik Hadi, Michele Silvestro, Hengdong Qu, Andrew Kumpfbeck, Rayan Sleiman, Kissinger Hyppolite Fils, Dornazsadat Alebrahim, Francesco Boccalatte, Matthias Kugler, Annanina Corsica, Bruce E Gelb, Glenn Jacobowitz, George Miller, Chiara Bellini, Jessica Oakes, Jean-Sébastien Silvestre, Lior Zangi, Bhama Ramkhelawon. Nature communications. 2020 August;11:4311. [Full Text Article] [PubMed:32855420] [PMC:PMC7453029]

Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior. Matthew G Frank, Laura K Fonken, Samuel D Dolzani, Jessica L Annis, Philip H Siebler, Dominic Schmidt, Linda R Watkins, Steven F Maier, Christopher A Lowry. Brain, behavior, and immunity. 2018 October;73:352-363. [Full Text Article] [PubMed:29807129] [PMC:PMC6129419]

Clinical Significance of High-Mobility Group Box 1 Protein (HMGB1) and Nod-Like Receptor Protein 3 (NLRP3) in Patients with Ulcerative Colitis. YanMin Chen, Dong Wu, LingJia Sun. Medical science monitor : international medical journal of experimental and clinical research. 2020 Jan;26:e919530. [Full Text Article] [PubMed:31901930] [PMC:PMC6977607]

Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma. Jianfeng Guo , Zhuo Yu , Dandan Sun, Yifang Zou, Yun Liu, Leaf Huang. Molecular cancer. 2021 Jan;20:10. [Full Text Article] [PubMed:33407548] [PMC:PMC7786897]

A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer. Dandan Sun, Yifang Zou, Liu Song, Shulan Han, Hao Yang, Di Chu, Yun Dai, Jie Ma, Caitriona M O'Driscoll, Zhuo Yu, Jianfeng Guo. Acta pharmaceutica Sinica. B. 2022 January;12:378-393. [Full Text Article] [PubMed:35127393] [PMC:PMC8799998]

Serum HMGB1 level is correlated with serum I-FABP level in neonatal patients with necrotizing enterocolitis. Ruyahan Huo, Heng Liu, Jing Chen, Hong Sheng, Li Miao. BMC pediatrics. 2021 August;21:355. [Full Text Article] [PubMed:34418984] [PMC:PMC8379747]

High-mobility group box 1 at the time of parturition in women with gestational diabetes mellitus. Ashley V Hill, Ramkumar Menon, Maria Perez-Patron, Genny Carrillo, Xiaohui Xu, Brandie D Taylor. American journal of reproductive immunology (New York, N.Y. : 1989). 2019 November;82:e13175. [Full Text Article] [PubMed:31353785] [PMC:PMC8135071]

Tourniquet use following blast-associated complex lower limb injury and traumatic amputation promotes end organ dysfunction and amplified heterotopic ossification formation. Philip J Spreadborough, Amy L Strong, John Mares, Benjamin Levi, Thomas A Davis. Journal of orthopaedic surgery and research. 2022 September;17:422. [Full Text Article] [PubMed:36123728] [PMC:PMC9484189]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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