Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
HLA-F belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.
Gene Name: | major histocompatibility complex, class I, F heavy chain |
Synonyms: | HLA-F, CDA12, HLAF, HLA-CDA12, MHC class I antigen F, HLA F antigen, MHC class Ib antigen, HLA-5.4, Leukocyte antigen F |
Target Sequences: | NM_018950 NP_061823.2 P30511 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.