HLA-DRB4

major histocompatibility complex, class II, DR beta 4

HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

HLA-DRB4 (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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HLA-DRB4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101777

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27 kDa

Price:

100 µg/$494

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Human HLA-DRB4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87994

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27 kDa

Price:

20 µg/$150

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Human HLA-DRB4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70789

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27 kDa

Price:

20 µg/$1,107

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Human HLA-DRB4 Protein (Recombinant GST) (Full Length) - LS-G28843

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

51.81 kDa

Price:

10 µg/$479; 25 µg/$670

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