HLA-DRB4

major histocompatibility complex, class II, DR beta 4

HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

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Products

Antibodies (17)

Type

Primary (17)

Target

HLA-DRB4 (17)

Reactivity

Human (17)

Mouse (1)

Application

IHC (6)

IHC-P (2)

WB (17)

ELISA (14)

Host

rabbit (15)

mouse (2)

Product Group

IHCPlus (1)

Isotype

IgG (15)

IgG2b,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (16)

Clone

4C8 (1)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (9)

Epitope

aa43-72 (7)

Publications

No (17)

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HLA-DRB4 Antibody (clone 4C8) LS-C133245

Antibody:

HLA-DRB4 Mouse anti-Human Monoclonal (4C8) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$423

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IHC-plus™ HLA-DRB4 Antibody LS-B15742

(4.0) Rating

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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HLA-DRB4 Antibody (HRP) LS-C377149

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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HLA-DRB4 Antibody (Biotin) LS-C377145

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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HLA-DRB4 Antibody (FITC) LS-C377138

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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HLA-DRB4 Antibody LS-C496790

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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HLA-DRB4 Antibody LS-C830596

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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HLA-DRB4 Antibody (aa43-72) LS-C321994

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal (aa43-72) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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HLA-DRB4 Antibody (aa43-72, Biotin) LS-C215110

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal (aa43-72) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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HLA-DRB4 Antibody (aa43-72, FITC) LS-C215111

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal (aa43-72) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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HLA-DRB4 Antibody (aa43-72, APC) LS-C215109

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal (aa43-72) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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HLA-DRB4 Antibody (aa43-72, Azide-free, HRP) LS-C215112

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal (aa43-72) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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HLA-DRB4 Antibody (aa43-72, PE) LS-C215113

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal (aa43-72) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

HLA-DRB4 Antibody LS-C666153

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$351

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HLA-DRB4 Antibody LS-C832095

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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HLA-DRB4 Antibody (aa43-72) LS-C164921

Antibody:

HLA-DRB4 Rabbit anti-Human Polyclonal (aa43-72) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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HLA-DRB4 Antibody LS-C308264

Antibody:

HLA-DRB4 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$705

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