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HLA-DRA

Major Histocompatibility Complex, class II, DR alpha

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.

Gene Name: Major Histocompatibility Complex, class II, DR alpha
Synonyms: HLA-DRA, HLA-DRA1, MHC cell surface glycoprotein, MHC class II antigen DRA, MLRW
Target Sequences: NM_019111 NP_061984.2 P01903

Publications (2)

1
Assessment of the genetic basis of rosacea by genome-wide association study. Chang ALS, Raber I, Xu J, Li R, Spitale R, Chen J, Kiefer AK, Tian C, Eriksson NK, Hinds DA, Tung JY. The Journal of investigative dermatology. 2015 135:1548-1555. (IHC; Human) [Full Text Article] [PubMed:25695682] [PMC:PMC4434179]
2
Secukinumab, a novel anti-IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity. Karle A, Spindeldreher S, Kolbinger F. mAbs. 2016 8:536-50. (WB; Human) [Full Text Article] [PubMed:26817498] [PMC:PMC4966846]

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Antibodies (87)
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HLA-DRA (87)
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monoclonal mc (23)
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No (87)
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HLA-DRA Mouse anti-Human Monoclonal (Concentrated) (HL39) Antibody
Human
Flo, IP
Unconjugated, Concentrated
0.1 mg/$471
HLA-DRA Antibody - Western blot of recombinant HLA-DRA.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HLA-DRA Rabbit anti-Cow Polyclonal (aa26-216) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$322; 200 µl/$370; 500 µl/$529; 1 ml/$614; 2 ml/$846; 5 ml/$1,393
HLA-DRA Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
HLA-DRA Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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HLA-DRA Rat anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-Fr
Unconjugated
200 µg/$732
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HLA-DRA Rat anti-Human Monoclonal (HRP) Antibody
Human
Flo, IHC
HRP Conjugated
100 µl/$951
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HLA-DRA Rat anti-Human Monoclonal (Biotin) Antibody
Human
Flo, IHC
Biotin Conjugated
100 µl/$951
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HLA-DRA Rat anti-Human Monoclonal (FITC) Antibody
Human
Flo, IHC
FITC Conjugated
100 µl/$951
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HLA-DRA Rat anti-Human Monoclonal (PE) Antibody
Human
Flo, IHC
PE Conjugated
100 µl/$951
HLA-DRA Antibody - Fig-1: Cell surface staining of PBMC (lymphocytes gated). Green: FITC conjugated Isotope control. Red: FITC conjugated anti-HLADR, clone AB3. 0.2 ug antibodies were used.
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HLA-DRA Mouse anti-Human Monoclonal (FITC) (AB3) Antibody
Human
Flo
FITC Conjugated
25 µg/$288; 100 µg/$414
HLA-DRA Antibody - 1:100 staining human gastric tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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HLA-DRA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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HLA-DRA Mouse anti-Human Monoclonal (HL39) Antibody
Human
Flo, IHC, IP
Unconjugated
100 µg/$711
HLA-DRA Antibody - Immunohistochemistry of paraffin-embedded Human liver using HLA-DRA Polyclonal Antibody at dilution of 1:100 (40x lens).
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HLA-DRA Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
HLA-DRA Antibody - Western blot of HLA-DRA Antibody in HL60 cell line lysates (35 ug/lane). HLA-DRA (arrow) was detected using the purified antibody.
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HLA-DRA Rabbit anti-Human Polyclonal (aa149-177) Antibody
Human
Flo, IHC, WB
Unconjugated
400 µl/$393
HLA-DRA Antibody - Immunohistochemistry of paraffin-embedded human tonsil tissue using HLA-DRA Antibody at dilution of 1:20
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HLA-DRA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
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HLA-DRA Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
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HLA-DRA Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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HLA-DRA Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
HLA-DRA Antibody - Western blot of recombinant HLA-DRA.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HLA-DRA Rabbit anti-Human Polyclonal (aa27-216) Antibody
Mouse, Human
ICC, IP, WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
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HLA-DRA Mouse anti-Human Monoclonal (1C11A5) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
HLA-DRA Antibody - IHC staining of FFPE human prostate cancer with HLA-DR antibody (clone TAL 1B5). HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
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HLA-DRA Mouse anti-Human Monoclonal (TAL 1B5) Antibody
Human
Flo, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
HLA-DRA Antibody - IHC staining of FFPE human prostate cancer with HLA-DR antibody (clone TAL 1B5). HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
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HLA-DRA Mouse anti-Human Monoclonal (Azide-free, BSA-free) (TAL 1B5) Antibody
Human
Flo, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
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HLA-DRA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$341
HLA-DRA Antibody - Western blot of extracts of Raji cell lines, using HLA-DRA antibody.
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HLA-DRA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
HLA-DRA Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer tissue  using HLA-DRA Polyclonal Antibody at dilution of 1:30(×200)
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HLA-DRA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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HLA-DRA Mouse anti-Human Monoclonal (LN-3) Antibody
Human
IHC
Unconjugated
1 ml/$836
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).