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6737 Mowry Ave
Newark, CA 94560
United States
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HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants.
| Gene Name: | major histocompatibility complex, class II, DQ beta 1 |
| Synonyms: | HLA-DQB1, Lymphocyte antigen, MHC class II DQ beta chain, MHC class2 antigen, MHC class II antigen DQB1, HLA-DQB, IDDM1, CELIAC1, MHC DQ beta |
| Target Sequences: | P01920 |
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