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Newark, CA 94560
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HLA-DMB
major histocompatibility complex, class II, DM beta
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
| Gene Name: | major histocompatibility complex, class II, DM beta |
| Synonyms: | HLA-DMB, D6S221E, DMB, MHC class II antigen DMB, MHC class II HLA-DMB, RING7 |
| Target Sequences: | NM_002118 NP_002109.2 P28068 |
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