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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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HLA-DMA
major histocompatibility complex, class II, DM alpha
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
| Gene Name: | major histocompatibility complex, class II, DM alpha |
| Synonyms: | HLA-DMA, DMA, RING6, D6S222E, HLADM, MHC class II antigen DMA |
| Target Sequences: | NM_006120 NP_006111.2 P28067 |
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