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HK2 / Hexokinase 2

hexokinase 2

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

Gene Name: hexokinase 2
Family/Subfamily: Non-protein Kinase , Hexokinase
Synonyms: HK2, Hexokinase II, Hexokinase type II, Hexokinase-2, muscle, HK II, HXK2, Hexokinase-2, Muscle form hexokinase, Hexokinase 2, HKII, Hxk 2
Target Sequences: NM_000189 NP_000180.2 P52789

Publications (2)

1
p53 Protects Cells from Death at the Heatstroke Threshold Temperature. Lu Gong, Qinghe Zhang, Xiao Pan, Shuming Chen, Lina Yang, Bin Liu, Weijun Yang, Luyang Yu, Zhi-Xiong Xiao, Xin-Hua Feng, Haihe Wang, Zhi-Min Yuan, Jinrong Peng, Wei-Qiang Tan, Jun Chen. Cell reports. 2019 Dec;29:3693-3707e5. [Full Text Article] [PubMed:31825845] Related Antibodies: LS-B3571.
2
Cdh1-mediated Skp2 degradation by dioscin reprogrammes aerobic glycolysis and inhibits colorectal cancer cells growth. Li Zhou, Xinfang Yu, Ming Li, Guanghui Gong, Wenbin Liu, Tian Li, Huilan Zuo, Wei Li, Feng Gao, Haidan Liu. EBioMedicine. 2020 Jan;51:102570. [Full Text Article] [PubMed:31806563] [PMC:PMC7000337] Related Antibodies: LS-C404653.

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Antibodies (76)
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HK2 / Hexokinase 2 (76)
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HK2 / Hexokinase 2 Antibody - Anti-HK2 / Hexokinase 2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal (aa74-123) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
HK2 / Hexokinase 2 Antibody - Anti-HK2 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HK2.
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HK2 / Hexokinase 2 Mouse anti-Human Monoclonal (OTI4C5) Antibody
Dog, Human
Flo, IF, WB
Unconjugated
100 µl/$450
HK2 / Hexokinase 2 Antibody - Anti-HK2 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HK2.
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HK2 / Hexokinase 2 Mouse anti-Human Monoclonal (Carrier-free) (OTI4C5) Antibody
Dog, Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
HK2 / Hexokinase 2 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
HK2 / Hexokinase 2 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using HK2 Polyclonal Antibody at dilution of 1:60.
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HK2 / Hexokinase 2 Antibody - Anti-HK2 / Hexokinase 2 antibody IHC staining of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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HK2 / Hexokinase 2 Mouse anti-Human Monoclonal (3D3) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$460
HK2 / Hexokinase 2 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal (aa401-431) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal Antibody
Human, Monkey
ELISA, IP, WB
Unconjugated
100 µl/$688
HK2 / Hexokinase 2 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using HK2 Polyclonal Antibody at dilution of 1:40.
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HK2 / Hexokinase 2 Antibody - HK2 Antibody in Immunohistochemistry (IHC)
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HK2 / Hexokinase 2 Mouse anti-Human Monoclonal (3D3) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$541
HK2 / Hexokinase 2 Antibody - Western Blot (WB) analysis using HXK II Monoclonal Antibody against PC12, HeLa, Jurkat cell lysate.
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HK2 / Hexokinase 2 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Pig, Human
WB
Unconjugated
50 µg/$332; 100 µg/$406; 200 µg/$505
HK2 / Hexokinase 2 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded esophagus cancer tissues (left) and Human Lung Cancer (right) with DAB staining using HXK II Monoclonal Antibody.
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HK2 / Hexokinase 2 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
HK2 / Hexokinase 2 Antibody - Immunofluorescent analysis of Hexokinase 2 staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal (aa91-121) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal (aa401-431) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal (aa401-431) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal (aa401-431) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal (aa401-431) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal (aa401-431) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
HK2 / Hexokinase 2 Antibody - Immunofluorescent analysis of PC3 cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
HK2 / Hexokinase 2 Antibody - Western blot of recombinant HK2 / Hexokinase 2.
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal (aa469-669) Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
HK2 / Hexokinase 2 Antibody - HK2 monoclonal antibody (M01), clone 4H1. Western Blot analysis of HK2 expression in PC-12.
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HK2 / Hexokinase 2 Mouse anti-Human Monoclonal (4H1) Antibody
Rat, Human
ELISA, WB
Unconjugated
100 µg/$423
HK2 / Hexokinase 2 Antibody - Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with HK2 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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HK2 / Hexokinase 2 Rabbit anti-Human Polyclonal (aa91-121) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).