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Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
Gene Name: | Holliday junction recognition protein |
Synonyms: | HJURP, DKFZp762E1312, FAKTS, Fetal liver expressing gene 1, FLEG1, HFLEG1, Up-regulated in lung cancer 9, URLC9 |
Target Sequences: | NM_018410 NP_060880.3 Q8NCD3 |
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