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Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.
Gene Name: | Histatin 3 |
Synonyms: | HTN3, Basic histidine-rich protein, Histatin 3, Histidine-rich protein 3, Histatin 5, Hst, HTN2, HTN5, HIS2, Histatin-3 |
Target Sequences: | NM_000200 NP_000191.1 P15516 |
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